Author

David Glen Esplin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 2

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Aaron M. HorningiD· 2 shared Annika K K WeimeriD· 2 shared Christina N. CurtisiD· 2 shared Edward D. EspliniD· 2 shared Emma MonteiD· 2 shared James M. FordiD· 2 shared Jeanne SheniD· 2 shared Meredith A. MillsiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Aaron M. HorningORCID

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2 papers

Recent·Most cited

Polyclonal origins of human premalignant colorectal lesions

Debra Van Egeren, Ryan O. Schenck, Aziz Khan, Aaron M. Horning, Shanlan Mo, Clemens L. Weiß, Edward D. Esplin, Winston R. Becker, Si Wu, Casey Ryan Hanson, Nasim Bararpour, Lihua Jiang, Kévin Contrepois, Hayan Lee, Stephanie A. Nevins, , Christina N. Curtis

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

Nature · Nov 25, 2025Peer-reviewedCancer Biology

Single-cell spatial mapping reveals alteration of tissue microenvironment during early colorectal cancer

Tuhin Kumar Guha, Edward D. Esplin, Aaron M. Horning, Roxanne Chiu, Kristina Paul, Annika K K Weimer, Winston R. Becker, Rozelle Laquindanum, Meredith A. Mills, David Glen Esplin, Jeanne Shen, Emma Monte, Shannon M. White, Thomas V. Karathanos, Daniel J. Cotter, , Michael P. Snyder

The paper uses spatial CODEX experiments to show early colorectal cancer microenvironment changes in FAP, including CAFs, immune suppression, and beta-catenin nuclear translocation.

bioRxiv · Nov 20, 2024 · PreprintCancer Biology