Author

James D. Thomas

University of FloridaORCID 0000-0002-8893-6350Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Alfredo CiccodicolaiD· 1 shared Alice H. BergeriD· 1 shared Austin M. GabeliD· 1 shared Ching-San TsengiD· 1 shared David A. NellesiD· 1 shared Florian KrachiD· 1 shared Franjo IvankoviciD· 1 shared Gene Wei-Ming YeoiD· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBioinformatics

Alfredo CiccodicolaORCID

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3 papers

Recent·Most cited

Discovery of synthetic lethal and tumor suppressive paralog pairs in the human genome

Phoebe C. R. Parrish, James D. Thomas, Austin M. Gabel, Shriya Kamlapurkar, Robert K. Bradley, Alice H. Berger

The paper identifies synthetic lethal and tumor suppressive paralog pairs in the human genome using a CRISPR-based approach, revealing new drug targets and essential gene families.

Cell Reports · Aug 1, 2021Peer-reviewedGenomics

RBPMetaDB: A comprehensive annotation of mouse RNA-Seq datasets with perturbations of RNA-binding proteins

Jin Li, Su-Ping Deng, Jacob Vieira, James D. Thomas, Valerio Costa, Ching-San Tseng, Franjo Ivankovic, Alfredo Ciccodicola, Peng Yu

RBPMetaDB compiles and organizes 278 mouse RNA-Seq datasets perturbed by 163 RNA-binding proteins, revealing unexplored proteins and enriched DNA-binding activities.

Database · Jan 1, 2018Peer-reviewedBioinformatics

Reversal of molecular pathology by RNA-targeting Cas9 in a myotonic dystrophy mouse model

Ranjan Batra, David A. Nelles, Florian Krach, James D. Thomas, Lukasz Snjader, Steven M. Blue, Stefan Aigner, Maurice S. Swanson, Gene Wei-Ming Yeo

RNA-targeting Cas9 reverses molecular pathology in a myotonic dystrophy mouse model by eliminating toxic CUG RNA and restoring normal cellular functions.

bioRxiv · Sep 4, 2017 · PreprintMolecular Biology