Pranav Kannan

The paper shows that collagen abundance alone does not define fibrosis in DMD, as distinct matrix states with different biological activities and mechanosignaling exist.

This study develops a platform for designing protein inhibitors against Dbl family GEFs, demonstrating their ability to modulate GEF activity in vitro and in cells with high specificity.

The paper designs immunogens that redirect immune responses to a conserved influenza epitope using iterative machine learning and in vivo testing.

This study uses multi-omics analysis to show that sarcospan overexpression in mdx mice compensates for dystrophin deficiency by altering cytoskeleton-matrix interactions and mechanotransduction pathways.