Author

Mihai L. Azoitei

Duke UniversityORCID 0000-0002-4080-1350Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:protein structure· 2 Research Focus:host-pathogen & immune response· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Caitlin HarrisiD· 4 shared Brianna RhodesiD· 3 shared Daniel J. MarstoniD· 3 shared Jayani ChristopheriD· 3 shared Anyway Brenda KapingidzaiD· 2 shared Heman Burre· 2 shared Kevin J. WieheiD· 2 shared McKenzie Frazier· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Caitlin HarrisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Control of Guanine Exchange Factor Activity Using De Novo Designed Protein Inhibitors

Fabiola Vacca, Daniel J. Marston, Caitlin Harris, Pranav Kannan, Heman Burre, Jayani Christopher, Irina Dumbravanu, Mihai L. Azoitei

This study develops a platform for designing protein inhibitors against Dbl family GEFs, demonstrating their ability to modulate GEF activity in vitro and in cells with high specificity.

bioRxiv · May 28, 2026 · PreprintCell Biology

A Mammalian Surface Display Platform to Optimize the Antigenicity of Viral Proteins for Vaccine Design

Jayani Christopher, Caitlin Harris, Daniel J. Marston, Brianna Rhodes, McKenzie Frazier, Mihai L. Azoitei

This paper develops a mammalian surface display platform using the PiggyBac transposon system to screen viral protein variants for improved antigenicity in vaccine design.

bioRxiv · Jan 12, 2026 · PreprintImmunology

Iterative immunogen optimization to focus elicited responses on a conserved, subdominant influenza hemagglutinin epitope

Daniel J. Marston, Akiko Watanabe, Anyway Brenda Kapingidza, Caitlin Harris, Elizabeth S. Van Itallie, Kapil Devkota, Jayani Christopher, Peiying Liu, Beena Pun, Brianna Rhodes, McKenzie Frazier, Kaitlyn Winters, Heman Burre, Pranav Kannan, Xiaoe Liang, , Mihai L. Azoitei

The paper designs immunogens that redirect immune responses to a conserved influenza epitope using iterative machine learning and in vivo testing.

bioRxiv · Nov 4, 2025 · PreprintImmunology

Design of SARS-CoV-2 RBD Immunogens to Focus Immune Responses Towards Conserved Coronavirus Epitopes

Caitlin Harris, Anyway Brenda Kapingidza, James Emmanuel San, Jayani Christopher, Tyler D. Gavitt, Brianna Rhodes, Katarzyna Janowska, Christopher O’Donnell, Jared J. Lindenberger, Xiao Yan Huang, Salam Sammour, Madison Berry, Maggie Barr, Robert Parks, Amanda Newman, , Mihai L. Azoitei

This paper designs SARS-CoV-2 RBD immunogens that shift immune responses towards conserved epitopes, improving cross-reactivity against variants.

Journal of Virology · Jun 13, 2025Peer-reviewedImmunology