Chandrashekhar G. Joshi

This study identifies ellagic acid as an inhibitor of EZH2 and PRMT5:MEP50, showing reduced histone modifications and tumor growth in mouse models.

This study shows that EGCG inhibits PRMT5 and EZH2 in breast cancer cells and xenografts, reducing histone repressive marks and inducing apoptosis and autophagy.

This study identifies indole-containing compounds that disrupt HSP90-HIF1α interactions by binding to the C-terminal ATP site, showing potential for repurposing tryptamine derivatives to treat hypoxic tumors.