Laurent Venance

This study investigates how the gut-brain vagal axis influences mesolimbic dopamine dynamics and reward behaviors, challenging the traditional brain-centric view of reward processing.

This study identifies endocannabinoid-mediated long-term potentiation (eCB-LTP) as a mechanism for one-shot learning in the dorsal striatum using a novel behavioral test and computational modeling.

The paper identifies a novel dopaminergic critic signal in mice during operant tasks that predicts correct/incorrect choices before reward signals, suggesting a role in learning and strategy adjustment.

This study shows that HTT phosphorylation recruits KIF1A to enhance axonal transport of synaptic vesicle precursors, increasing glutamate release and impairing motor learning in mice.

This study examines rhythmic oscillations in midbrain dopaminergic nuclei of mice during task performance, finding phase-locked activity in specific frequency bands linked to behavioral events.

This paper develops a deep learning tool to automatically score bradykinesia using MDS-UPDRS III protocols, showing significant correlation with gold-standard ratings.

This paper measures impedance of neural tissue across different preparations and shows frequency-dependent behavior that cannot be explained by resistive models, attributing it to ionic diffusion in Debye layers.

The paper shows lactate and glucose are differentially used for neuronal fueling based on memory load and engram complexity.

The paper shows that cerebellar stimulations reduce or prevent levodopa-induced dyskinesia in mice by normalizing brain activity and reversing neuronal plasticity.

This study shows BDNF/TrkB signaling promotes endocannabinoid-mediated plasticity (LTD and LTP) in striatum through calcium-dependent eCB synthesis and release.

The paper shows opto-activation of cortical somatostatin interneurons alleviates motor symptoms in a Parkinson's mouse model.

This study shows that cannabinoids induce long-term depression by remodeling presynaptic vesicle pools through actomyosin contractility.

The paper investigates how spike timing jitter affects three forms of STDP at corticostriatal synapses, finding that endocannabinoid-mediated plasticity is more robust than NMDAR-mediated plasticity.

This study identifies odor-specific neuronal ensembles in the mouse piriform cortex as necessary and sufficient for odor fear memory recall.