Frédéric Saudou

This study identifies early motor learning deficits and corticostriatal network alterations in a Huntington's disease mouse model before motor symptoms appear.

This study shows that HTT phosphorylation recruits KIF1A to enhance axonal transport of synaptic vesicle precursors, increasing glutamate release and impairing motor learning in mice.

This study shows that Akt phosphorylation of Huntingtin regulates axonal transport of APP and presynaptic levels, affecting synaptic homeostasis and learning.

This study shows that increasing HTT phosphorylation at Ser421 improves BDNF transport, striatal BDNF availability, and the phenotype of Mecp2 knockout mice.

This study shows that ATAT1-enriched vesicles are transported along axons to acetylate -tubulin, essential for proper vesicular transport.

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.

This study shows that impaired AMPA receptor surface diffusion contributes to synaptic plasticity and memory deficits in Huntington’s disease, and that tianeptine can restore these functions.