Thomas Foltynie

This study identifies six novel genetic loci associated with Parkinson's disease mortality and motor progression using genome-wide survival analysis.

This paper predicts subthalamic nucleus beta bursts in Parkinson's disease using deep learning, identifying a predictive biomarker for burst onset.

This study shows GLP-1R agonism improves Parkinson's disease by restoring neuronal insulin signaling and reducing glial inflammation, with clinical benefits in patients with higher baseline MAPK expression.

This paper identifies three novel genetic variants associated with levodopa-induced dyskinesia in Parkinson's disease and confirms associations with ANKK1 and BDNF, while also finding gender, age at onset, and anxiety as risk factors.

The paper examines neural correlates of conflict and evidence integration during sequential decision making, finding increased cortico-subthalamic coherence and prolonged subthalamic beta oscillations during conflict.

The paper identifies human-lineage-specific genomic elements, called CNCRs, and shows their enrichment in neurological disease genes and APOE intron-3 retention transcripts in Alzheimer's disease.

This paper identifies genetic variants associated with cognitive and motor progression in Parkinson's disease using GWAS and longitudinal cohort data.

This study shows that alternating subthalamic nucleus deep brain stimulation can entrain stepping rhythms in Parkinson's patients, suggesting the STN's role in step timing control.

The paper investigates how high-frequency activity in the basal ganglia co-varies with motor cortical beta oscillations during motor control and rest in Parkinson's patients.

This study shows that ropinirole, a dopamine agonist, impairs proactive inhibition in healthy adults, suggesting a mechanism for impulse control disorders in Parkinson's patients.

The paper examines the structural and functional connectivity of the nucleus basalis of Meynert in Parkinson's disease dementia and Lewy body dementia using MEG and MRI tractography.

This study identifies cell-type-specific expression of dystonia-associated genes and links them to shared genetic and biological mechanisms with psychiatric disorders.

The paper identifies signatures of the hyperdirect pathway and its role in pathological network disruption in Parkinson's disease through multimodal analysis.

The paper identifies disease-relevant regulatory loci in human basal ganglia using genomic and transcriptomic data from 117 brains, highlighting splicing eQTLs and ASE analyses as sources of cell-specific regulatory information.

Across 37,688 Parkinson's cases, 18,618 proxy-cases and 1.4M controls, 90 risk signals map to 78 loci (37 new); an 1805-variant polygenic score explains 26-36% of heritability.

The paper introduces a new parameter, VS, to detect bradykinesia in Parkinson's disease patients using the BRAIN tap test and validates its reliability across different hardware platforms.

This study connects Parkinson’s disease heritability to cell-type-specific gene regulation, finding enrichment in lysosomal genes in astrocytic and microglial subtypes rather than specific cell types or brain regions.

This study uses whole-brain computational modeling to analyze how deep brain stimulation affects brain dynamics in Parkinson’s disease patients, finding it shifts brain states closer to healthy dynamics.