Cassandra M. Barrett

This study quantifies polygenic liability in rare disease probands and finds associations between rare disease phenotypes and polygenic scores, supporting complex trait influences on Mendelian variant interpretation.

The paper shows that components from the c-myb transcriptional system can reactivate epigenetically silenced transgenes using CRISPR activation in mammalian cells.

This study characterizes ten homoserine lactone synthases in E. coli, showing their compatibility with the Lux pathway and highlighting disposal risks of HSLs.

The paper shows that transcriptional activation of silenced chromatin enhances CRISPR activity by reducing histone trimethylation and increasing gene expression.