David R. Peale

PATHFINDER improves neuron reconstruction accuracy and efficiency in mouse brain connectome mapping by reducing error rates and manual effort.

The paper describes an automated ultra-microtome for TEM sectioning, achieving high success rates in cutting and picking up sections from various biological samples.

The paper introduces GCIB-SEM, a 3D electron microscopy technique that provides <10 nm isotropic resolution for large volumes, improving z-resolution and compatibility with multibeam SEMs.