Julie A. Schneider

This study identifies genetic loci and pathways associated with limbic white matter microstructure in aging and Alzheimer's Disease using multi-cohort diffusion MRI and bulk RNA-seq data.

This paper introduces a computational pipeline for genotyping TOMM40 poly-T polymorphisms from whole-genome sequencing data, achieving high accuracy and consistency with PCR-based genotypes.

The paper identifies microglia subsets in ALS brain and spinal cord, finding an undifferentiated phenotype and enrichment of interferon response microglia in aggressive cases.

The paper identifies sex-specific genetic loci associated with memory, executive functioning, and language performance in older adults through genome-wide meta-analyses.

This study examines the association between APOE genotype and cognitive resilience in SuperAgers, finding lower APOE-ε4 and higher APOE-ε2 frequencies in non-Hispanic White SuperAgers compared to controls and Alzheimer's cases.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

The paper develops eigen-polygenic risk scores (ePRSs) from clustered subnetworks of single-trait PRSs and shows they improve prediction of Alzheimer's Disease and related phenotypes.