The paper develops eigen-polygenic risk scores (ePRSs) from clustered subnetworks of single-trait PRSs and shows they improve prediction of Alzheimer's Disease and related phenotypes.

Human Molecular Genetics · Apr 27, 2024Peer-reviewedGenetics

CHRNA5 links chandelier cells to severity of amyloid pathology in human aging and Alzheimer's Disease

Jonas Rybnicek, Yuxiao Chen, Milos S. Milic, Earvin S. Tio, JoAnne McLaurin, Timothy J. Hohman, Philip L. De Jager, Julie A. Schneider, Yanling Wang, David Alan Bennett, Shreejoy J. Tripathy, Daniel Felsky, Evelyn K. Lambe

The paper investigates CHRNA5's role in amyloid pathology in aging and Alzheimer's by analyzing genetic variants and cell-type expression in human brain tissue.

Translational Psychiatry · Feb 8, 2024Peer-reviewedNeuroscience

Sleep-insomnia superposition: opposing brain signatures of sleep in task-based and resting-state conditions

Mohamed Abdelhack, Peter Zhukovsky, Milos S. Milic, Shreyas Harita, Michael Wainberg, Shreejoy J. Tripathy, John David Griffiths, Sean Hill, Daniel Felsky

The paper examines correlations between task and resting-state brain signatures of sleep, cognition, and depression in over 30,000 individuals, revealing opposing neural patterns associated with insomnia and depression.

Nature Communications · Dec 1, 2023Peer-reviewedNeuroscience

Testing a polygenic risk score for morphological microglial activation in Alzheimer's disease and aging

Earvin S. Tio, Timothy J. Hohman, Milos S. Milic, David A. Bennett, Daniel Felsky, the Alzheimer’s Disease Neuroimaging Initiative

The paper tests a polygenic risk score for microglial activation in Alzheimer's disease and aging, finding no significant improvement in predictive power for AD diagnosis or cognitive performance.

Journal of Alzheimer s Disease · Jul 11, 2023Peer-reviewedGenetic & Genomic Medicine