Author

John A. Gaynes

University of Colorado AnschutzORCID 0000-0003-0772-4071Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:imaging· 3 Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alon Poleg-PolskyiD· 3 shared Michael J. Grybko· 2 shared Samuel Alexander BudoffiD· 2 shared Alexandra W. Fuller· 1 shared Amanda Morris· 1 shared Anne M. Danks· 1 shared Anthony R. Chavez· 1 shared Aryan Alavi· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Alon Poleg-PolskyORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Incomplete remyelination via endogenous or therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function

Gustavo Della‐Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael Andrew Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne Woerner, Deidre A. MacKenna, Aryan Alavi, Anne M. Danks, , Ethan G. Hughes

This study shows that partial oligodendrocyte restoration after demyelination is sufficient to recover visual cortical function in mice.

Nature Communications · Jan 16, 2025Peer-reviewedNeuroscience

Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.

John A. Gaynes, Samuel Alexander Budoff, Michael J. Grybko, Alon Poleg-Polsky

This study investigates how presynaptic kinetics contribute to directional tuning in starburst amacrine cells using computational models and experimental data.

bioRxiv · Aug 2, 2023 · PreprintNeuroscience

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis

Xiaodong Li, Patrick J. Gordon, John A. Gaynes, Alexandra W. Fuller, Randy Ringuette, Clayton P. Santiago, Valerie A. Wallace, Seth Blackshaw, Pulin Li, Edward M. Levine

This study shows Lhx2 modulates Sonic Hedgehog signaling in retinal progenitors through direct and indirect regulation of pathway components, establishing competence for signaling during early neurogenesis.

eLife · Nov 10, 2022Peer-reviewedDevelopmental Biology

Novel Object Detection and Multiplexed Motion Representation in Retinal Bipolar Cells

John A. Gaynes, Samuel Alexander Budoff, Michael J. Grybko, Joshua B. Hunt, Alon Poleg-Polsky

This study investigates how center-surround receptive field interactions in retinal bipolar cells contribute to motion processing by detecting novel objects and encoding motion through altered signal dynamics.

bioRxiv · May 13, 2021 · PreprintNeuroscience