Clayton P. Santiago

This study shows that blocking apoptosis in retinal organoids increases RGC survival but delays their development, highlighting apoptosis's role in regulating RGC quantity and dynamics.

This study investigates the role of Sox8 and Sox9 in retinal Muller glia differentiation and nuclear positioning using genetic and single-cell multiomic approaches.

This study identifies DIO3 as a regulator of photoreceptor development timing and fate stability in human retinal organoids, proposing an hourglass model for developmental progression.

This study shows Ptbp1 is not required for retinal neurogenesis or cell fate specification, contradicting prior claims of its role as a master regulator.

This study shows that overexpressing Meis1 and Meis2 in postnatal mouse retinal progenitor cells has distinct effects on temporal identity and neurogenesis, without fully reprogramming cell fate.

The paper identifies conserved and species-specific aging mechanisms in retinal cells across zebrafish, mice, and humans using single-cell multi-omics analyses.

This study compares single-cell and single-nucleus RNA-seq in a rabbit PVR model, finding similar gene expression profiles but differences in cell type capture rates and fibrotic cell representation.

The paper identifies mechanisms that generate M/L cone dominance and suppress S cones in the human foveola using retinal organoids and signaling pathway regulators.

This study shows Lhx2 modulates Sonic Hedgehog signaling in retinal progenitors through direct and indirect regulation of pathway components, establishing competence for signaling during early neurogenesis.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.

This study transplants human retinal organoids into mice and identifies two classes of graft-derived cells with distinct migration and maturation behaviors.

This study identifies gene regulatory networks controlling retinal development by integrating single-cell RNA and ATAC-seq data from mouse and human retinas, revealing transcription factors that regulate temporal patterning and cell fate.

The paper uses transcriptomic analysis to compare gene expression in control and TAO patients' orbital fat and differentiating orbital fibroblasts, identifying IGF-1R and Wnt signaling pathway differences.

This study identifies gene regulatory networks controlling proliferative and neurogenic competence in retinal Muller glia.

ASCOT identifies key regulators of neuronal subtype-specific splicing by analyzing public RNA-Seq data and demonstrating the role of PTBP1, MSI1, and PCBP2 in rod photoreceptor splicing.