Author

Ruxandra Dafinca

John Radcliffe HospitalORCID 0000-0003-0776-6431Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Kevin TalbotiD· 2 shared Alicia LjungdahliD· 1 shared Ana CandalijaiD· 1 shared Andrew G. L. DouglasiD· 1 shared Britt HansoniD· 1 shared David SimsiD· 1 shared Dhanu GuptaiD· 1 shared Dongnan Yan· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Kevin TalbotORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular TherapyPeer-reviewedDec 11, 2025

Targeted BDNF upregulation via upstream open reading frame disruption

Feng Ning, Thomas Goedert, Nenad Svrzikapa…·Thomas C. Roberts

This study identifies uORF elements regulating BDNF translation and demonstrates that disrupting uORFs can upregulate BDNF expression in cell culture.

6 citations

humanexperimental assay

𝕏 PostBluesky

NeuroscienceHuman Molecular GeneticsPeer-reviewedJun 1, 2020

Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by CRISPR/Cas9 genome editing using homology-directed repair

Nidaa A. Ababneh, Jakub Scaber, Rowan Flynn…·Kevin Talbot

This study corrects a C9orf72 hexanucleotide expansion in iPSC-derived motor neurons using CRISPR/Cas9 and HDR, restoring normal gene expression and eliminating pathological phenotypes.

75 citations

humanCRISPR screen

𝕏 PostBluesky