Author

Dongnan Yan

John Radcliffe Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Dhanu GuptaiD· 2 shared Matthew J. A. WoodiD· 2 shared Alicia LjungdahliD· 1 shared André GörgensiD· 1 shared Antje Maria ZickleriD· 1 shared Britt HansoniD· 1 shared Doste Rashid MamandiD· 1 shared Elien Van WonterghemiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

Dhanu GuptaORCID

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Author profile →

2 papers

Recent·Most cited

Systemic Inflammation Modulates Clearance and drives Extra-Hepatic Distribution of Extracellular Vesicles

Svetlana Pavlova, Doste Rashid Mamand, André Görgens, Antje Maria Zickler, Wenyi Zheng, Xiuming Liang, Oscar P. B. Wiklander, Manuchehr Abedi‐Valugerdi, Elien Van Wonterghem, Junhua Xie, Zheyu Niu, Samantha Roudi, Dongnan Yan, Ruhani Makkar, Guannan Zhou, , Samir EL Andaloussi

This study shows that systemic inflammation significantly prolongs EV plasma half-life and enhances their accumulation in inflamed organs like the liver and spleen.

Journal of Extracellular Vesicles · Apr 1, 2026Peer-reviewedBioengineering

Targeted BDNF upregulation via upstream open reading frame disruption

Feng Ning, Thomas Goedert, Nenad Svrzikapa, Dongnan Yan, Hans J. Friedrichsen, Britt Hanson, Alicia Ljungdahl, Ruxandra Dafinca, Kevin Talbot, Stephan Sanders, Dhanu Gupta, Matthew J. A. Wood, Thomas C. Roberts

This study identifies uORF elements regulating BDNF translation and demonstrates that disrupting uORFs can upregulate BDNF expression in cell culture.

Molecular Therapy · Dec 11, 2025Peer-reviewedMolecular Biology