Jack Frew

This study identifies PIEZO1 as a mechanosensor driving inflammation-permissive macrophage phenotypes in synovial tissue, contributing to joint inflammation in RA.

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

This study shows that PROS1 released by lung basal cells during SARS-CoV-2 infection reduces inflammation, promotes epithelial repair, and enhances antigen presentation.

This study identifies distinct myeloid DC subsets in synovial tissue across health and RA states, showing their roles in inflammation and tolerance.