This study compares chondrogenic differentiation of iPSC-derived chondroprogenitors (iCPs) and MSCs in alginate hydrogels, finding iCPs show superior cartilage formation with enhanced matrix composition.

bioRxiv · Sep 10, 2026 · PreprintCell Biology

Beyond mean trabecular separation: decomposing metaphyseal marrow space into local trabecular spacing and marrow cavity expansion

Carmen Huesa, John C. Lockhart, Carl S. Goodyear, Jonathan A. Williams

The paper decomposes trabecular separation into local trabecular spacing and marrow cavity expansion to better understand metaphyseal bone changes in osteoporosis, spinal cord injury, ovariectomy, and ageing.

bioRxiv · Jun 18, 2026 · PreprintBioengineering

Synovial lining expressed mechanosensor PIEZO1 drives inflammation-permissive macrophage phenotypes and joint inflammation

Theodoros Simakou, Marcus Doohan, Carmen Huesa, Kieran Woolcock, Domenico Somma, Watipenge Harmony Nyasulu, Shreya Prakash, Kieran A. Boyle, Luxin Yang, Binghua Darren Zhang, Denise Campobasso, Clara Di Mario, Andrew Farthing, Jack Frew, Lavinia Agra Coletto, , Mariola Kurowska‐Stolarska

This study identifies PIEZO1 as a mechanosensor driving inflammation-permissive macrophage phenotypes in synovial tissue, contributing to joint inflammation in RA.

bioRxiv · Jan 13, 2026 · PreprintImmunology

Nanovibrational stimulation of osteogenesis engages non-canonical Wnt signalling and NF-κB regulator BCL3 as a mechanotransducer

Hussain Jaffery, Udesh Dhawan, Jonathan A. Williams, Carmen Huesa, Ruaidhrı́ J. Carmody, James F. C. Windmill, Stuart D. Reid, Peter G. Childs, Manuel Salmerón‐Sánchez, Matthew John Dalby

This study shows nanovibrational stimulation promotes osteogenesis in mesenchymal stromal cells via non-canonical Wnt signaling and BCL3 regulation.

bioRxiv · Jul 24, 2025 · PreprintBioengineering