Marcus Doohan

This study identifies mitochondrial transfer from M2-like macrophages to AML cells as a mechanism of chemoresistance, showing that LIMK inhibition and metformin block this transfer and restore chemosensitivity.

This study identifies PIEZO1 as a mechanosensor driving inflammation-permissive macrophage phenotypes in synovial tissue, contributing to joint inflammation in RA.

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

This study shows that PROS1 released by lung basal cells during SARS-CoV-2 infection reduces inflammation, promotes epithelial repair, and enhances antigen presentation.