Reagan S. Andersen

This study shows that Atxn10 is essential for embryonic heart development and adult kidney and pancreas function, with loss leading to lethality and epithelial to mesenchymal transition.

The paper identifies an evolutionarily conserved genetic interaction between nphp-4 and bbs-5 mutations that exacerbates ciliopathy phenotypes across C. elegans, zebrafish, and mice.

This study creates Bbs5 mouse models to investigate ciliary function, revealing developmental origins of specific BBS phenotypes like pituitary anomalies and infertility.

This study generates domain-specific mutations in the zebrafish ndr2 gene using CRISPR-Cas9 RNPs, resulting in cyclopia and providing insights into the gene's structure-function relationship.