Alberto Pérez-Posada

This study shows cell cycle exit is necessary for terminal differentiation but not neoblast specialization in planarians, with lineage commitment occurring in cycling neoblasts.

The paper integrates single cell transcriptomics and chromatin accessibility data to uncover the regulatory logic of planarian stem cell differentiation, validating predictions with TF knockdown experiments.

This study uses scRNA-seq to investigate cell type allometry in planarians, finding that gut basal cells respond most to size changes.

The paper constructs a Hydractinia cell atlas to study the cellular and molecular mechanisms of coloniality, finding that distinct colony parts are defined by combinations of shared cell types and rare innovations.

This study identifies and characterizes adult cell types and their pluripotent origins in the annelid Pristina leidyi using single-cell transcriptomics.

The paper uses multiplex single-cell transcriptomics to study serotonergic neuron function in planarians, revealing widespread effects on diverse cell types and suggesting glial-like roles for parenchymal cells.

The paper identifies a periodic transcriptional program in Capsaspora owczarzaki, showing similarities to animal cell cycle regulation and suggesting an intermediate state in the evolution of cyclin-CDK systems.