Helena García-Castro

The paper integrates single cell transcriptomics and chromatin accessibility data to uncover the regulatory logic of planarian stem cell differentiation, validating predictions with TF knockdown experiments.

The paper constructs a Hydractinia cell atlas to study the cellular and molecular mechanisms of coloniality, finding that distinct colony parts are defined by combinations of shared cell types and rare innovations.

The paper constructs a single-cell RNA sequencing atlas of spider embryos, revealing cell clusters, gene expression patterns, and developmental insights into arthropod embryogenesis.

This study identifies and characterizes adult cell types and their pluripotent origins in the annelid Pristina leidyi using single-cell transcriptomics.

The paper uses multiplex single-cell transcriptomics to study serotonergic neuron function in planarians, revealing widespread effects on diverse cell types and suggesting glial-like roles for parenchymal cells.

The paper introduces ACME, a cell fixation-dissociation method for single-cell transcriptomics that preserves RNA integrity and enables cryopreservation and sorting, validated with SPLiT-seq in planarians.