Jordi Solana

Comparative larval single-cell transcriptomics provides insights into the evolutionary origins of sensory-neural programmes in Porifera and Cnidaria

The paper compares larval single-cell transcriptomes of sponges and cnidarians to explore the evolutionary origins of neural and sensory cell types.

Cell cycle exit is required for differentiation and cell fate diversification but not neoblast specialisation in planarians

This study shows cell cycle exit is necessary for terminal differentiation but not neoblast specialization in planarians, with lineage commitment occurring in cycling neoblasts.

A sex-specific regulator expands the embryonic ocular field to generate a novel visual system

The Regulatory Logic of Planarian Stem Cell Differentiation

The paper integrates single cell transcriptomics and chromatin accessibility data to uncover the regulatory logic of planarian stem cell differentiation, validating predictions with TF knockdown experiments.

Evolutionarily conserved transcriptional regulators control monoaminergic neuron development

The paper identifies conserved transcriptional regulators in monoaminergic neuron development across species using single-cell genomics and spatial transcriptomics.

Allometry of cell types in planarians by single cell transcriptomics

This study uses scRNA-seq to investigate cell type allometry in planarians, finding that gut basal cells respond most to size changes.

The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality

The paper constructs a Hydractinia cell atlas to study the cellular and molecular mechanisms of coloniality, finding that distinct colony parts are defined by combinations of shared cell types and rare innovations.

An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis

The paper constructs a single-cell RNA sequencing atlas of spider embryos, revealing cell clusters, gene expression patterns, and developmental insights into arthropod embryogenesis.

Annelid adult cell type diversity and their pluripotent cellular origins

This study identifies and characterizes adult cell types and their pluripotent origins in the annelid Pristina leidyi using single-cell transcriptomics.

Multiplex single-cell analysis of serotonergic neuron function in planarians reveals widespread effects in diverse cell types

The paper uses multiplex single-cell transcriptomics to study serotonergic neuron function in planarians, revealing widespread effects on diverse cell types and suggesting glial-like roles for parenchymal cells.

ACME dissociation: a versatile cell fixation-dissociation method for single-cell transcriptomics

The paper introduces ACME, a cell fixation-dissociation method for single-cell transcriptomics that preserves RNA integrity and enables cryopreservation and sorting, validated with SPLiT-seq in planarians.

Graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

This paper introduces PAGA, a method that reconciles clustering with trajectory inference by creating a topology-preserving graph map of single-cell data, demonstrating its effectiveness across multiple datasets.