BiochemistryCommunications BiologyPeer-reviewed
Dynamic allostery drives acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2
Evelyn Yu‐Wen Huang, Brooke X. C. Kwai, Wanting Jiao…·Ivanhoe K. H. Leung
This paper identifies how acetyl-CoA binding induces allostery in Mycobacterium tuberculosis ICL2, revealing a novel mechanism for enzyme activation and potential therapeutic targets.
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