Author

Jamie R. H. Taka

University of AucklandORCID 0000-0002-1418-9540Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Brooke X. C. KwaiiD· 2 shared Evelyn Yu‐Wen HuangiD· 2 shared Ghader BashiriiD· 2 shared Ivanhoe K. H. LeungiD· 2 shared Wanting JiaoiD· 2 shared Ashish SethiiD· 1 shared James JungiD· 1 shared Karyn L. WildeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

Brooke X. C. KwaiORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 9, 2026

Time-resolved cryo-EM reveals conformational trajectory of allosteric activation in isocitrate lyase

Jamie R. H. Taka, James Jung, Shuning Guo…·Ghader Bashiri

The paper uses time-resolved cryo-EM to show how acetyl-CoA binding induces conformational changes in ICL2, leading to asymmetric catalytic activity.

DOI 10.64898/2026.04.08.716820

cryo-EMmicroscopy & imaging analysis

𝕏 PostBluesky

BiochemistryCommunications BiologyPeer-reviewedMar 9, 2026

Dynamic allostery drives acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Evelyn Yu‐Wen Huang, Brooke X. C. Kwai, Wanting Jiao…·Ivanhoe K. H. Leung

This paper identifies how acetyl-CoA binding induces allostery in Mycobacterium tuberculosis ICL2, revealing a novel mechanism for enzyme activation and potential therapeutic targets.

1 citation

experimental assay

𝕏 PostBluesky