Author

Evelyn Yu‐Wen Huang

The University of MelbourneORCID 0000-0002-3071-9759Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Ivanhoe K. H. LeungiD· 3 shared Brooke X. C. KwaiiD· 2 shared Ghader BashiriiD· 2 shared Jamie R. H. TakaiD· 2 shared Wanting JiaoiD· 2 shared Anna K. CoussensiD· 1 shared Ashish SethiiD· 1 shared Christopher K. BarlowiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiochemistry

Ivanhoe K. H. LeungORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A mixer tap mechanism in Mycobacterium tuberculosis regulates a critical metabolic node in response to nutrient availability

Evelyn Yu‐Wen Huang, Katherine J. Jeppe, Jingsong Zhou, Christopher K. Barlow, Jemila C. Kester, Anna K. Coussens, Ivanhoe K. H. Leung

The paper identifies a regulatory mechanism in Mycobacterium tuberculosis that controls metabolic flux through coordinated enzyme abundance and metabolite effects, likened to a mixer tap.

bioRxiv · May 3, 2026 · PreprintBiochemistry

Time-resolved cryo-EM reveals conformational trajectory of allosteric activation in isocitrate lyase

Jamie R. H. Taka, James Jung, Shuning Guo, Wanting Jiao, Brooke X. C. Kwai, Luiz Pedro S. de Carvalho, Matthew B. McNeil, Evelyn Yu‐Wen Huang, Zhiheng Yu, Ivanhoe K. H. Leung, Ghader Bashiri

The paper uses time-resolved cryo-EM to show how acetyl-CoA binding induces conformational changes in ICL2, leading to asymmetric catalytic activity.

bioRxiv · Apr 9, 2026 · PreprintBiochemistry

Dynamic allostery drives acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Evelyn Yu‐Wen Huang, Brooke X. C. Kwai, Wanting Jiao, Jamie R. H. Taka, Karyn L. Wilde, Ashish Sethi, Megan J. Maher, Ghader Bashiri, Ivanhoe K. H. Leung

This paper identifies how acetyl-CoA binding induces allostery in Mycobacterium tuberculosis ICL2, revealing a novel mechanism for enzyme activation and potential therapeutic targets.

Communications Biology · Mar 9, 2026Peer-reviewedBiochemistry