Pan-cancer circular genomics identifies intratumoral Staphylococcus lugdunensis as a metabolic driver in bladder cancer
Tao Wang, Ming Zhao, Conghui Li, Zhuofan Bai, Fan Zhang, Hongyun Zhao, Wei Lv, Chunhua Lin, Duanyang Kong, Xiaolu Zhao, P Wang, Fengbiao Mao
This paper develops CIRCMIP to profile intratumoral microbiota, identifies Staphylococcus lugdunensis as a bladder cancer biomarker, and reveals its metabolic role via LPC14:0-PPARδ signaling.
bioRxiv · Apr 16, 2026 · PreprintCancer Biology