Author

Laura Chacon Machado

Cornell UniversityORCID 0000-0003-0865-4001Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Approach:statistical model· 1

Frequent Co-Authors

Joseph E. PetersiD· 2 shared Alba GuarnéiD· 1 shared Jordan E. ThesieriD· 1 shared Richard D. SchargeliD· 1 shared Shravanika Kumaran· 1 shared

Activity by Year

2025-2025 · peak 2/yr

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5 top collaborators · 10 mutual co-author links

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2 shared papersMolecular Biology

Joseph E. PetersORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintAug 27, 2025

De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems

Richard D. Schargel, Laura Chacon Machado, Shravanika Kumaran…·Joseph E. Peters

This paper engineers de novo RNA-guided transposition systems using TnpB-family proteins, showing improved specificity and efficiency compared to naturally evolved systems.

2 citations

CRISPR screenexperimental assay

𝕏 PostBluesky

Molecular BiologyMobile DNAPeer-reviewedFeb 18, 2025

A family of Tn7-like transposons evolved to target CRISPR repeats

Laura Chacon Machado, Joseph E. Peters

The paper identifies a novel group of Tn7-like transposons in Cyanobacteria that target CRISPR arrays, revealing a new interaction between transposons and CRISPR-Cas systems.

3 citations

C. elegansstatistical model

𝕏 PostBluesky