BiochemistrybioRxivPreprint
Unveiling the biochemical catalysis and regulatory mechanisms of the E3-independent E2 enzyme hUBE2O
Dan Xiang, Xiaoxiao Tang, Ruona Shi…·Xiaofei Zhang
This study elucidates the catalytic and regulatory mechanisms of hUBE2O, revealing its unique architecture for mono- and polyubiquitination and identifying key residues and zinc ions as regulators.
DOI 10.1101/2025.06.27.661974