Xiaofei Zhang

A Phospho-Switch for Cell Fate Control

The paper identifies a phospho-switch in SALL4 that controls cell fate by modulating BAF complex interaction in response to BMP4-DUSP9 signaling, causing developmental defects when disrupted.

Unveiling the biochemical catalysis and regulatory mechanisms of the E3-independent E2 enzyme hUBE2O

This study elucidates the catalytic and regulatory mechanisms of hUBE2O, revealing its unique architecture for mono- and polyubiquitination and identifying key residues and zinc ions as regulators.

PSMC2 and CXCL8-Modulated Four Critical Gene Biomarkers and Druggable and Vaccinable Targets for Colorectal Cancer

The paper identifies four critical differentially expressed genes in colorectal cancer using transcriptomic data from multiple cohorts and validates their predictive power and potential as druggable/vaccinable targets.

Long-Read Sequencing of the Zebrafish Genome Reorganizes Genomic Architecture

The paper uses nanopore sequencing to improve the zebrafish reference genome assembly, identifying novel structural variants and retrotransposon integration sites.