Paolo De Coppi

This paper evaluates two cryopreservation strategies for amniotic fluid cells to improve organoid derivation efficiency and identifies an optimal freezing medium.

The paper characterizes transcriptional changes in gastroschisis, showing that prenatal repair normalizes gene expression and bowel dilation.

This study identifies neutrophil myeloperoxidase (MPO) as a biomarker for RSV severity and demonstrates its utility as a functional readout for evaluating antiviral therapies in an in vitro model.

This study shows that ECM defects in Down syndrome neurodevelopment cause apical cytoarchitecture and mechanical property instability in neural stem cell models.

This paper establishes a fetal lamb model of complex gastroschisis, showing it reproducibly induces structural and functional bowel changes at term, with higher incidence at later post-induction intervals.

The paper develops multi-regional gastric assembloids from patient-derived organoids to model parietal cell maturation and antral foveolar hyperplasia in genetic disorders.

This study demonstrates that transplanting human pluripotent stem cell-derived enteric nervous system progenitors can improve contractile function and rescue molecular pathways in Hirschsprung disease colonic tissue.

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

This study uses multi-omics approaches to identify molecular and epigenetic changes in NEC, revealing Ezh2's role in maintaining intestinal stem cells and epithelial regeneration.

This paper investigates VEGF supplementation as a treatment for congenital diaphragmatic hernia (CDH)-associated lung abnormalities using an ex vivo model and nanoparticle-based delivery in vivo.

The paper demonstrates that extracellular vesicles from amniotic fluid stem cells can rescue impaired fetal lung development in experimental models.