This study conducts a large-scale GWAS meta-analysis across East Asian populations, identifying 8,010 new associations and revealing shared and population-specific genetic architectures for 127 complex traits.

bioRxiv · Jun 23, 2026 · PreprintGenetics

Population-Specific Polygenic Risk Scores Developed for the Han Chinese

Hung‐Hsin Chen, Chien-Hsiun Chen, Ming‐Chih Hou, Yun‐Ching Fu, Ling‐Hui Li, Che-Yu Chou, Erh‐Chan Yeh, Ming-Fang Tsai, Chun-houh Chen, Hsin‐Chou Yang, Yen‐Tsung Huang, Yi-Min Liu, Chun-Yu Wei, Jen-Ping Su, Wan-Jia Lin, , Chih‐Yang Huang

The paper develops population-specific polygenic risk scores for Han Chinese using genomic and electronic health record data, showing strong predictive performance for multiple diseases.

Nature · Oct 15, 2025Peer-reviewedGenetic & Genomic Medicine

Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

Chun-Yu Wei, Ming‐Shien Wen, Chih-Kuang Cheng, Yi‐Jing Sheen, Tsung‐Chieh Yao, Sing-Lian Lee, Jer-Yuarn Wu, Ming-Fang Tsai, Ling-Hui Li, Chun‐Houh Chen, Cathy S.-J. Fann, Hsin‐Chou Yang, Yen‐Tsung Huang, Hung-Hsin Chen, Yi-Min Liu, , Chien‐Ming Lin

The paper evaluates the clinical impact of pharmacogenetic risk variants in a large Han Chinese cohort, finding that while most carry risk variants, the excess risk of adverse events is small and most patients do not experience adverse outcomes.

Nature Communications · Jul 9, 2025Peer-reviewedGenetic & Genomic Medicine

Subtyping of major SARS-CoV-2 variants reveals different transmission dynamics

Hsin‐Chou Yang, Jen-Hung Wang, Chih-Ting Yang, Yin-Chun Lin, Han‐Ni Hsieh, Po-Wen Chen, Hsiao-Chi Liao, Chun‐Houh Chen, James C. Liao

The paper subtypes SARS-CoV-2 variants and identifies SNVs associated with transmission differences across multiple genomic datasets.

PNAS Nexus · Sep 1, 2022Peer-reviewedBioinformatics