Author

Hsueh-Ju Lu

Chung Shan Medical University Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:GWAS summary statistics· 2 Research Focus:variant effect prediction· 2 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:GWAS / association mapping· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Chih‐Hung LaiiD· 3 shared Ching‐Heng LiniD· 3 shared Erh‐Chan YehiD· 3 shared Hsin TungiD· 3 shared Hsin-Chien YeniD· 3 shared Hsin‐Chou YangiD· 3 shared Hung‐Hsin CheniD· 3 shared I-Chieh CheniD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Chih‐Hung LaiORCID

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3 papers

Recent·Most cited

Population-Specific Polygenic Risk Scores Developed for the Han Chinese

Hung‐Hsin Chen, Chien-Hsiun Chen, Ming‐Chih Hou, Yun‐Ching Fu, Ling‐Hui Li, Che-Yu Chou, Erh‐Chan Yeh, Ming-Fang Tsai, Chun-houh Chen, Hsin‐Chou Yang, Yen‐Tsung Huang, Yi-Min Liu, Chun-Yu Wei, Jen-Ping Su, Wan-Jia Lin, , Chih‐Yang Huang

The paper develops population-specific polygenic risk scores for Han Chinese using genomic and electronic health record data, showing strong predictive performance for multiple diseases.

Nature · Oct 15, 2025Peer-reviewedGenetic & Genomic Medicine

Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

Chun-Yu Wei, Ming‐Shien Wen, Chih-Kuang Cheng, Yi‐Jing Sheen, Tsung‐Chieh Yao, Sing-Lian Lee, Jer-Yuarn Wu, Ming-Fang Tsai, Ling-Hui Li, Chun‐Houh Chen, Cathy S.-J. Fann, Hsin‐Chou Yang, Yen‐Tsung Huang, Hung-Hsin Chen, Yi-Min Liu, , Chien‐Ming Lin

The paper evaluates the clinical impact of pharmacogenetic risk variants in a large Han Chinese cohort, finding that while most carry risk variants, the excess risk of adverse events is small and most patients do not experience adverse outcomes.

Nature Communications · Jul 9, 2025Peer-reviewedGenetic & Genomic Medicine

Deleterious Variants Contribute Minimal Excess Risk in Large-Scale Testing

Yen‐Tsung Huang, En‐Yu Lai, Jia-Ying Su, Hsueh-Ju Lu, Yen‐Lin Chen, Jer-Yuarn Wu, Chunyu Wei, Ling‐Hui Li, Cathy S.J. Fann, Hsin‐Chou Yang, Chien-Hsiun Chen, Hung‐Hsin Chen, Yi-Min Liu, Ming-Fang Tsai, Erh‐Chan Yeh, , Chang‐Hsun Hsieh

The paper analyzes 292 disease-relevant deleterious variants in 486,956 participants to assess their risk differences, finding most have minimal impact.

medRxiv · Oct 21, 2024 · PreprintGenetic & Genomic Medicine