Muneer G. Hasham

This study shows that genetically distinct tumor microenvironments in mice affect cancer growth, survival, and therapy response, independent of cancer cell properties or immune system.

This paper describes methods to study xenografted human cancer in genetically diverse mice to better understand tumor behavior and identify suitable hosts.

The paper identifies the transcriptional activation of Jun and Fos genes in the AP-1 complex as a conserved aging signature in immune cells, contributing to inflammaging across mouse strains and humans.