Author

Melania Bruno

National Institutes of HealthORCID 0000-0002-8401-7744Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Todd S. MacfarlaniD· 4 shared Apratim MitraiD· 2 shared Sherry RallsiD· 2 shared Alberto De IacoiD· 1 shared André NussenzweigiD· 1 shared Anne C. Ferguson‐SmithiD· 1 shared Ben E. BlackiD· 1 shared Beth L. DumontiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersGenetics

Todd S. MacfarlanORCID

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4 papers

Recent·Most cited

Young KRAB-zinc finger gene clusters are highly dynamic incubators of ERV-driven genetic heterogeneity in mice

Melania Bruno, Sharaf M. Farhana, Apratim Mitra, Kevin R Costello, Dawn E. Watkins‐Chow, Glennis A. Logsdon, Craig W. Gambogi, Beth L. Dumont, Ben E. Black, Thomas Keane, Anne C. Ferguson‐Smith, Ryan Dale, Todd S. Macfarlan

The paper analyzes young KRAB-zinc finger gene clusters in mice, showing ERVs drive genetic heterogeneity through recombination and duplication mechanisms.

Nature Communications · Oct 30, 2025Peer-reviewedGenetics

Meiosis-specific decoupling of the pericentromere from the kinetochore

Bo Pan, Melania Bruno, Todd S. Macfarlan, Takashi Akera

The paper identifies a meiosis-specific pericentromere specification in Peromyscus mouse oocytes that separates sister-chromatid cohesion from the kinetochore.

Nature Communications · Mar 3, 2025Peer-reviewedCell Biology

Dual Histone Methyl Reader ZCWPW1 Facilitates Repair of Meiotic Double Strand Breaks

Mohamed Mahgoub, Jacob Paiano, Melania Bruno, Wei Wu, Sarath Pathuri, Xing Zhang, Sherry Ralls, Xiaodong Cheng, André Nussenzweig, Todd S. Macfarlan

This study identifies ZCWPW1 as a dual histone methylation reader essential for meiotic DSB repair in vertebrates, showing its co-expression and co-evolution with PRDM9.

eLife · Apr 30, 2020Peer-reviewedGenetics

Non-essential function of KRAB zinc finger gene clusters in retrotransposon suppression

Gernot Wolf, Alberto De Iaco, Ming‐an Sun, Melania Bruno, Matthew Tinkham, Don Hoang, Apratim Mitra, Sherry Ralls, Didier Trono, Todd S. Macfarlan

The paper shows that deleting large KRAB-ZFP gene clusters in mice leads to retrotransposon activation, indicating most KRAB-ZFPs are non-essential for transposon suppression.

bioRxiv · Jan 17, 2020 · PreprintGenetics