Raphael H. Valdivia

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

This study identifies epigenetic phase variation in the gut microbiome, showing it enhances bacterial adaptation through gene regulation and bet-hedging strategies.

This study compares four Akkermansia species to identify adaptations to mucin-rich environments, finding unique protein expression and metabolite profiles in A. muciniphila.

The paper identifies a pathobiont-epithelial IDO1 pathway that drives region-specific susceptibility to inflammatory bowel disease in the ascending colon.

The paper links genetic variation to pathogen-induced cellular traits and disease by integrating GWAS data with clinical and experimental validation.