Author

Agathe Subtil

Centre National de la Recherche ScientifiqueORCID 0000-0002-7481-4846Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Yongzheng WuiD· 3 shared Béatrice Niragire· 2 shared Chongfa Tang· 2 shared Félix V. LoucheziD· 2 shared Adrián Gabriel TorresiD· 1 shared Chang Liu· 1 shared Chloé I. CharendoffiD· 1 shared Cindy AdapeniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Yongzheng WuORCID

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3 papers

Recent·Most cited

Intracellular growth of Chlamydia trachomatis leads to global histone hypermethylation by impairing demethylation

Chloé I. Charendoff, Félix V. Louchez, Yongzheng Wu, Lee Dolat, Guillaume Velasco, Stéphanie Perrinet, Adrián Gabriel Torres, Laure Blanchet, Magalie Duchateau, Quentin Giai Gianetto, Mariette Matondo, Laurence Del Maestro, Slimane Ait‐Si‐Ali, Frédéric Bonhomme, Gaël A. Millot, , Agathe Subtil

This study shows that Chlamydia trachomatis infection causes global histone hypermethylation by inhibiting demethylation, leading to altered transcription and affecting infection outcomes.

eLife · Sep 14, 2026Peer-reviewedCell Biology

IFN-I exacerbates the inflammatory response of epithelial cells to Chlamydia trachomatis infection by enhancing TLR3 expression

Chongfa Tang, Xiaonan Cai, Béatrice Niragire, Félix V. Louchez, Y Levy-Zauberman, Agathe Subtil, Yongzheng Wu

This study shows that IFN-I enhances TLR3 expression in epithelial cells, leading to increased inflammation during Chlamydia trachomatis infection.

mBio · Jun 15, 2026Peer-reviewedMicrobiology

Chlamydia-driven ISG15 expression dampens the immune response of epithelial cells independently of ISGylation

Yongzheng Wu, Chang Liu, Chongfa Tang, Béatrice Niragire, Y. Levy-Zauberman, Cindy Adapen, Thomas Vernay, Juliette Hugueny, Véronique Baud, Agathe Subtil

This study shows that ISG15 expression in epithelial cells infected with Chlamydia trachomatis reduces inflammation and bacterial load without requiring ISGylation.

mBio · Sep 30, 2024Peer-reviewedMicrobiology