Mario Mörl

The paper identifies CCA2 enzymes in Asgard archaea and Heimdallarchaeia, challenging the evolutionary separation between archaeal and eukaryotic CCA-adding enzymes and supporting bacterial gene integration prior to eukaryogenesis.

The paper analyzes and characterizes mitochondrial tRNAs in nematodes and arachnids, revealing structural deviations and editing events not captured by genome-based predictions.

This study designs functional exoribonuclease-resistant RNAs using a mechanics-aware approach, achieving wild-type efficiency without sequence similarity to known xrRNAs.

The paper sequences four Perkinsus mitochondrial genomes, identifies conserved frameshifts in all genes, and proposes a decoding mechanism involving unused codons.

The paper identifies a beta-turn element in the Romanomermis culicivorax tRNA nucleotidyltransferase that enables full CCA-adding activity on armless tRNAs when transplanted into the human enzyme.

The paper designs synthetic neomycin-responsive riboswitches and shows that their function depends on sequence context, introducing in silico methods to improve design.