Author

Karen L. Eskow Jaunarajs

University of Alabama at BirminghamORCID 0000-0003-1011-4928Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:electronic health records· 1 Assay:scRNA-seq· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

David G. StandaertiD· 2 shared Mariangela ScarduzioiD· 2 shared David A. FiggeiD· 1 shared Henrique de Amaral Oliveira· 1 shared Jack Crim· 1 shared Rita Marie CowelliD· 1 shared Sophie C Gregoretti· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 12 mutual co-author links

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2 shared papersNeuroscience

David G. StandaertORCID

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3 papers

Recent·Most cited

NeuroscienceNeurobiology of DiseasePeer-reviewedOct 1, 2026

Altered Striatal Acetylcholine Dynamics in a Model of Parkinson Disease and L-DOPA-induced Dyskinesia

Sophie C Gregoretti, Karen L. Eskow Jaunarajs, Mariangela Scarduzio

This study investigates how dopamine depletion and L-DOPA treatment alter acetylcholine dynamics in the striatum of a Parkinson's disease model, revealing state-dependent changes in temporal organization of cholinergic signaling.

DOI 10.1016/j.nbd.2026.107636

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 15, 2024

Cholinergic Transmission in an Inducible Transgenic Mouse Model of Paroxysmal Dystonia

Mariangela Scarduzio, Karen L. Eskow Jaunarajs, David G. Standaert

The paper investigates cholinergic transmission in a mouse model of dystonia, finding that D2R-mediated paradoxical excitation of cholinergic interneurons is reversed by caffeine, suggesting a role in movement regulation.

DOI 10.1101/2024.03.15.585266

mouseelectronic health records

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 3, 2023

Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia.

David A. Figge, Henrique de Amaral Oliveira, Jack Crim…·Karen L. Eskow Jaunarajs

This study identifies differential activation states of D1-MSN subpopulations in response to L-DOPA treatment and links these changes to LID development through activin/TGFβ signaling.

DOI 10.1101/2023.11.03.565591

mousescRNA-seq

𝕏 PostBluesky