Author

David A. Figge

University of Alabama at BirminghamORCID 0000-0001-5737-575XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ashley S. HarmsiD· 2 shared Asta JurkuvenaiteiD· 2 shared David G. StandaertiD· 2 shared Jhodi M. WebsteriD· 2 shared Aidan T. MilleriD· 1 shared Aubrey M SchonhoffiD· 1 shared Gabrielle M. ChildersiD· 1 shared Gregory P. WilliamsiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Ashley S. HarmsORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 30, 2026

Stage-Specific NF-κB RelA and IRF4 Programs Drive -Synuclein-Induced Disease-Associated Microglia Differentiation

Yating Yang, Yves Greatti, Aidan T. Miller…·Ashley S. Harms

This study identifies NF-κB RelA and IRF4 as stage-specific regulators driving -synuclein-induced disease-associated microglia differentiation in Parkinson disease.

DOI 10.64898/2026.09.25.754514

humanbulk RNA-seq

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NeurosciencebioRxivPreprintNov 3, 2023

Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia.

David A. Figge, Henrique de Amaral Oliveira, Jack Crim…·Karen L. Eskow Jaunarajs

This study identifies differential activation states of D1-MSN subpopulations in response to L-DOPA treatment and links these changes to LID development through activin/TGFβ signaling.

DOI 10.1101/2023.11.03.565591

mousescRNA-seq

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NeuroscienceNature CommunicationsPeer-reviewedJun 26, 2023

Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease

Aubrey M Schonhoff, David A. Figge, Gregory P. Williams…·Ashley S. Harms

This study identifies border-associated macrophages (BAMs) as key mediators of alpha-synuclein-induced neuroinflammation in Parkinson's disease.

161 citationstop 1%

humanbulk RNA-seq

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