Automated Cytogenetic Biodosimetry at Population-Scale
Peter K. Rogan, R Lu, E Mucaki…·Joan H.M. Knoll
ADCI-HT automates dicentric chromosome detection and dose estimation for large-scale radiation incidents, achieving high throughput and accuracy.
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Health CanadaORCID 0000-0003-1055-5029Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Peter K. Rogan, R Lu, E Mucaki…·Joan H.M. Knoll
ADCI-HT automates dicentric chromosome detection and dose estimation for large-scale radiation incidents, achieving high throughput and accuracy.
Qing Liu, Chun Wang, Xiaozhen Jiao…·Kejian Wang
Hi-TOM is a high-throughput tool for tracking mutations induced by CRISPR/Cas systems, showing high reliability and sensitivity in detecting various mutations, including complex chimeric ones.
Jin Liu, Yanxin Li, Ruth C. Wilkins…·Peter K. Rogan
The paper improves radiation dose estimation by automating dicentric chromosome curation and metaphase cell selection, reducing false positives and increasing accuracy.
Akila Subasinghe, Jagath Samarabandu, Yanxin Li…·Peter K. Rogan
The paper presents a centromere detection algorithm for human metaphase chromosomes, achieving 87% accuracy by evaluating candidate locations using profile thickness measurements and correcting for sister chromatid separation.
Yanxin Li, Joan HM Knoll, Ruth Wilkins…·Peter K Rogan
The paper develops a machine learning-based method to automatically detect dicentric chromosomes from metaphase images, achieving acceptable accuracy across radiation doses.