Author

Howard D. White

Old Dominion UniversityORCID 0000-0003-1066-2051Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Cristina M. RisiiD· 2 shared Vitold E. GalkiniD· 2 shared Betty BelknapiD· 1 shared Betty Virok· 1 shared Charlotte A. ScarffiD· 1 shared David Paul KlebliD· 1 shared Donald A. WinkelmanniD· 1 shared Eva Forgacs· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

Cristina M. RisiORCID

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2 papers

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedAug 26, 2026

The structure of the native cardiac crossbridge in the rigor state.

Cristina M. Risi, Tyler M. Nguyen, Betty Belknap…·Vitold E. Galkin

This study reports the high-resolution structure of the native cardiac rigor cross-bridge, revealing how myosin heads and thin filament components coordinate during contraction.

DOI 10.1126/sciadv.aeg1209

cryo-EMexperimental assay

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BiochemistryNaturePeer-reviewedApr 9, 2025

Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM

David Paul Klebl, Sean N. McMillan, Cristina M. Risi…·Howard D. White

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

41 citationstop 1%

cryo-EMmicroscopy & imaging analysis

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