Corey G. Duke

The paper uses snRNA-seq to identify distinct D1-MSN subpopulations with differential transcriptional responses to cocaine in rats.

This paper improves CRISPR/dCas9 interference for neuronal gene suppression by using a dual lentivirus system and dCas9-KRAB-MeCP2 construct, showing superior repression of the Bdnf gene in rat neurons.

This study identifies a dopamine-induced gene expression signature in the nucleus accumbens that drives cocaine-induced physiological and behavioral adaptations in rats.

This study shows blue light exposure alters gene expression in cultured neurons, but this effect is due to phototoxic interactions between light and culture media, not direct neuronal activation.

This paper develops a neuron-optimized CRISPRa system for efficient and specific gene regulation in neurons and the adult brain.