Faraz A. Sultan

The paper evaluates the AICS-0090 dCas9-KRAB iPSC line for modeling microglia-like cells and their responses to disease-relevant stimuli, finding stimulus-specific transcriptomic and functional responses.

This paper improves CRISPR/dCas9 interference for neuronal gene suppression by using a dual lentivirus system and dCas9-KRAB-MeCP2 construct, showing superior repression of the Bdnf gene in rat neurons.

This study investigates the role of Gadd45b in dopamine-dependent transcription and cocaine reward, showing its necessity for cocaine-induced behavioral and epigenetic changes.

The paper identifies enhancer-gene regulatory links using eRNAs and shows their functional importance in neuronal systems.

This study identifies a dopamine-induced gene expression signature in the nucleus accumbens that drives cocaine-induced physiological and behavioral adaptations in rats.

This paper develops a neuron-optimized CRISPRa system for efficient and specific gene regulation in neurons and the adult brain.