Author

Poppy Sephton-Clark

Broad InstituteORCID 0000-0003-1103-6028Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:gene regulatory network inference· 2 Research Focus:GWAS / association mapping· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:fungi (other)· 1 Organism:human· 1

Frequent Co-Authors

Christina A. CuomoiD· 3 shared Adrienne Kit ChaniD· 1 shared Arturo CasadevalliD· 1 shared Cecilia KanyamaiD· 1 shared Charles D. GiamberardinoiD· 1 shared Christopher Kukacha· 1 shared Daniel F. Q. SmithiD· 1 shared Dena L. ToffalettiiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenomics

Christina A. CuomoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintMar 30, 2023

Impact of pathogen genetics on clinical phenotypes in a population of Talaromyces marneffei from Vietnam

Poppy Sephton-Clark, Thu N. M. Nguyen, Ngô Thị Hoa…·Christina A. Cuomo

The paper uses population genomics and GWAS to analyze Talaromyces marneffei isolates from Vietnam, linking pathogen genetics to clinical phenotypes and identifying genomic regions under selection.

DOI 10.1101/2023.03.30.534926

whole-genome sequencingstatistical model

𝕏 PostBluesky

GenomicsmBioPeer-reviewedNov 10, 2022

Genomic variation across a clinical Cryptococcus population linked to disease outcome

Poppy Sephton-Clark, Jennifer L. Tenor, Dena L. Toffaletti…·Christina A. Cuomo

This study links genetic variation in Cryptococcus neoformans to clinical outcomes and virulence in animal models using GWAS and genomic data from 284 isolates.

41 citationstop 2%

fungi (other)whole-genome sequencing

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GenomicsbioRxivPreprintApr 12, 2022

Human and murine Cryptococcus neoformans infection selects for common genomic changes in an environmental isolate.

Poppy Sephton-Clark, Scott A. McConnell, Nina T. Grossman…·Arturo Casadevall

The paper shows that environmental Cryptococcus neoformans strains undergo genomic and phenotypic changes during mammalian infection, suggesting animal virulence drives genetic adaptation.

2 citations

humanmouse

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