Author

Hilary M. Sheppard

University of AucklandORCID 0000-0003-1147-4618Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

David J. H. F. KnappiD· 2 shared Fanny-Meï Cloarec-UngiD· 1 shared Guy SauvageauiD· 1 shared Hector Barbosa· 1 shared Huw Colin‐YorkiD· 1 shared Marco FritzscheiD· 1 shared Mary Kay ThompsoniD· 1 shared Mike Bogetofte BarnkobiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

David J. H. F. KnappORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 15, 2026

Genome-wide structural variant landscape following HDR-enhanced CRISPR editing in human hematopoietic stem and progenitor cells

Fanny-Meï Cloarec-Ung, Guy Sauvageau, Hilary M. Sheppard…·David J. H. F. Knapp

The paper investigates structural variant induction in human hematopoietic stem and progenitor cells during HDR-enhanced CRISPR editing, finding that SVs occur even without DNA-PK inhibitors and increase with multiple edits.

DOI 10.64898/2026.06.13.732078

humanwhole-genome sequencing

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Synthetic BiologyNature CommunicationsPeer-reviewedFeb 18, 2019

Precise tuning of gene expression output levels in mammalian cells

Yale S. Michaels, Mike Bogetofte Barnkob, Hector Barbosa…·Tudor A. Fulga

This paper introduces miSFITs, synthetic microRNA response elements that allow precise control of gene expression levels in mammalian cells, showing their utility in modulating antigen expression in a mouse melanoma model.

66 citations

mouseCRISPR screen

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