Raquel Iniesta

LDSC++ improves heritability and genetic correlation estimation in multivariate GWAS by enhancing LD score regression with segmented regression and better handling of shared genetic variants and imputation quality.

The paper develops two gene expression classification models for Alzheimer’s Disease using blood-derived data, finding that including mixed controls improves specificity but reduces sensitivity.

The paper develops SPiQE, an automated tool to detect and characterize fasciculations in ALS using HDSEMG data, achieving high sensitivity and specificity.