Author

Max E. Douglas

Institute of Cancer ResearchORCID 0000-0003-1186-7163Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Angela Dello StrittoiD· 1 shared Ceylan SönmeziD· 1 shared Charlotte E L Fisher· 1 shared Charlotte E. L. Fisher· 1 shared Ciara Leonard-BookeriD· 1 shared Francisca LottersbergeriD· 1 shared Giulia MazzuccoiD· 1 shared Jörg MansfeldiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Angela Dello StrittoORCID

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2 papers

Recent·Most cited

Molecular BiologyThe EMBO JournalPeer-reviewedJul 9, 2026

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

Ciara Leonard-Booker, Giulia Mazzucco, Charlotte E L Fisher…·Max E. Douglas

This study investigates how telomeres impede replication by showing G-rich DNA and shelterin subunit POT1 block lagging strand replication, with POT1 causing Okazaki fragment skipping and large single-stranded gaps.

1 citation

humanDNA methylation

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BiochemistryNaturePeer-reviewedApr 16, 2025

Chromosome end protection by RAP1-mediated inhibition of DNA-PK

Patrik Eickhoff, Ceylan Sönmez, Charlotte E. L. Fisher…·Max E. Douglas

The paper shows RAP1 inhibits DNA-PK's end joining function at telomeres by forming a complex with TRF2, preventing telomere fusions.

9 citationstop 4%

humanmouse

𝕏 PostBluesky