Cancer BiologybioRxivPreprint
The Small Non-coding RNA miR-16-1-3p Hampers Cancer Stem Cell Self-renewal and Invasiveness, Boosting Chemosensitivity by Adjusting TGF-β1 Signaling via MDM2/p53 Axis in Human Osteosarcoma.
Wenyu Xue, Yuzhe Wang, Anna V. Smirnova…·Sergey V. Leonov
This paper shows miR-16-1-3p reduces cancer stem cell self-renewal and invasiveness in osteosarcoma by modulating TGF-β1 signaling through the MDM2/p53 axis, enhancing chemosensitivity to cisplatin.
DOI 10.1101/2025.11.19.689220