Gen‐Sheng Feng

This study shows that rapamycin reduces age-related liver damage caused by a high-fat diet in mice by reversing transcriptional changes and metabolic dysfunction.

This study identifies CD133+ vesicles as mediators of resistance to RAS-ERK inhibition in liver cancer, regulated by YAP activation under stress conditions.

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

The paper introduces ImAge, an image-based biomarker of aging and rejuvenation using chromatin and epigenetic patterns, showing correlation with chronological age and response to interventions.

The paper uses single-cell transcriptomics to analyze liver development in mice, identifying cell types, metabolic zonation, and a transient macrophage population.